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Home>Products>Testosterone Anabolic Steroid>High purity competitive price 606143-52-6 Pharmaceutical Raw Materials

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  • High purity competitive price 606143-52-6 Pharmaceutical Raw Materials
  • High purity competitive price 606143-52-6 Pharmaceutical Raw Materials
  • High purity competitive price 606143-52-6 Pharmaceutical Raw Materials
  • High purity competitive price 606143-52-6 Pharmaceutical Raw Materials

High purity competitive price 606143-52-6 Pharmaceutical Raw Materials

  • Selumetinib
  • Selumetinib

  • China
  • Selumetinib
  • 10g
  • Negotiable
  • 1kg/Aluminum foil bag
  • 3-5 days after received your deposit
  • MoneyGram, Western Union, D/P, T/T
  • 1000kg/month
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Zhongjian chemicals Co.,Ltd

Zhongjian chemicals Co.,LtdChina

  • Zhongjian chemicals Co.,Ltd2020-07-10 09:46:19
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Product Details

Model Number: Selumetinib Appearance: powder Purity: 99%
Production Capacity: 800kg/month Application: For Application DeliveryTime: 3-5 days after received your deposit
Storage: Keep dry Packing: Safe discreet packages through Customers Package: 1kg/Aluminum foil bag

Product Description

Selumetinib(CAS: 606143-52-6)

Product Name Selumetinib
Molecular Formula C17H15BrClFN4O3
Molecular Weight 457.685
Purity: 99%+
Product Specifications: Pharmaceutical Grade
MOQ(Minimum Order Quantity): 100g
Payment: L/C, T/T, Western Union
Shipment: EMS, DHL, FedEx
Brand: Newbio Pharm-Tech

Selumetinib (AZD6244; ARRY-142886) is a potent, highly selective MEK1 inhibitor with IC50 of 14 nM, also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc.

chemical name: 6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide

More informations about CAS 606143-52-6 Selumetinib (AZD6244), please inquiry us.

1.Inquiries will be replied within 24 hours
2.We could supply various packages as you required
3.To protect the profit of our agents, price will not show on website, please send inquiries to get the price.
4.Fast delivery, goods arrive your office within 3 to 5 days
5.Please click "Inquiry" or "Email" below to get the price
Synonyms :
AZD6244;Ar
Appearance :
Chemical Formula :
C17H15BrClFN4O3
Solubility :
DMSO 91 mg/mL warmed (198.82 mM)
Molecular Weight :
457.69
Storage and Stability :
in stock
CAS No. :
606143-52-6
Purity :
99%
Introduction
Selumetinib is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.AZD6244 is not competitive with ATP and inactivates the ERK1/2 phosphorylation with IC50 concentrations below 40 nM. AZD6244 also inhibits the growth of primary HCC cells through inhibition of ERK1/2 and p90RSK phosphorylation, accompanied with elevation of the cleavage of caspase-3 and caspase-7, and cleaved poly(ADP)ribose polymerase. AZD6244 has little effects on the p38, c-Jun-NH2-kinase, phosphatidylinositol 3-kinase, and MEK5/ERK5 pathways. AZD6244 is sensitive to Raf mutations in breast cancer cell lines and Ras mutations in NSCLC cell lines.

What is Selumetinib?

In the previous study, siamectin showed that siamectin had the effect of treating metastatic biliary tract cancer.
The first-line treatment strategy for low grade serous ovarian cancer is surgery followed by radiotherapy. However, this tumor growth is slow, poor response to traditional chemotherapy drugs. The MEK-1/2 protein kinase targeting the mitogen-activated protein kinase (MAPK) pathway was used to study the presence of MEK gene mutations due to low-grade serous ovarian or peritoneal carcinomas. The study was given to 52 patients with 100 mg of simitidone, orally twice daily for 4 weeks for 1 week of treatment and 33% of patients received 12 or more cycles of treatment. Before the study began, 58% of patients had received 3 or more chemotherapy. Siemetilide controls 81% of patients with disease. In particular, 8 patients received complete or partial remission, and 34 patients were stable. The median progression-free survival was 11 months and 63% had no progression of survival for more than 6 months. In addition, the patient was well tolerated with vinodone, and only 3 patients developed grade 4 adverse events.
MEK inhibitors (mitogen-activated inhibitors) have been used in clinical applications and can be first applied to the treatment of chronic pain, inhibition of cancer cell proliferation, treatment of non-small cell lung cancer, MEK inhibitors combined with nilotinib Chronic myeloid leukemia (CML) resistance. Recent treatment of metastatic biliary tract cancer and control of low grade serous ovarian or peritoneal cancer. Therefore, the MEK inhibitor siMedidine will become a new drug for the treatment of cancer.

Shipping & Delivery
1.Packages are generally dispatched within approximately 2 days after receipt of payment.
2.After the each shipping we will provide you with:
1) a link & tracking number to track your package online.
2) the few pictures with your order & details.
3.About the Custom clearance,we packed in disguise ways.In our experience,the appropriate and safe delivery,there won be problems.
4.We confirm 99% clearance,100% resending.
5.Is it the best & safest shipping for all our repeat customers!


Packing Details
Discreet packing ways as your requirement, 100% go through.
Storage
Store in cool and dry area and keep away from direct sunlight.oC
Shelf life
2 years, keep in formal storage condition.

MOQ
We accept any Qty you require, grams to kilograms.
Samples Available, Contact now!

Top reason why you choose us ?
(1)Fast discreet delivery with great shipping success!
(2)Pictures with your order & details!
(3)We will provide you the tracking number!
(4)Keep track of your goods untill the goods are sent in to your hands.
(5)We confirm 99% clearance,100% resending.
(6)High quality,100% pure products!
(7)Delivery time approx.4-6 business days.
(8)Best, Safe and Secure services.
(9)Customer support 24/7.


Order infos
Payment Methods:West Union,Moeny Gram, Bitcoin and Bank Transfer.
Delivery Ways:EMS,HKEMS,TNT,DHL,FedEX,UPS etc.
Shipment Time:Within 12 hours after confirmation of your payment
Other Service:Safe shipment,high purity and best price for you.

Applications:

Users of this steroid often report very good gains in strength along with a slight gain in quality muscle mass. T-bol is often used as a “jump start" to a cycle. Here the quick acting effects of the oral allow the bodybuilder to start experiencing gains and "pumps" early on, while the injectables being used in the cycle have more time to take effect. GP Turan is a very versatile steroid and can be used effectively in both cutting and bulking cycles. It stacks well with virtually all compounds, and is also effective at lowering SHBG in the body, thus making the other compounds, such as Testosterone, even more effective.

Specifications:

TEST ITEMS SPECIFICATION RESULTS
Appearance : White Or Practically White Crystalline Powder White Crystalline Powder
Melting range : ≥145℃ 145-147℃
Loss on drying : 0.5%max 0.29%
Assay(by GLC) : 98.00%min 99.00%
Conclusion The specification conform with enterprize standard

Competitive Advantage:

· High quality products;

· efficient service;

· safe shipping method.

4. productlist of steriods

hot sell products list
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Sustanon
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Methenolone Acetate 434-05-9
Methenolone Enanthate 303-42-4
Drostanolone Propionate 521-12-0
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Oxandrolone 53-39-4
Methandienone 72-63-9
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Oxymetholone 434-07-1
4-chloro-17a-methyl androst-
1,4 diene-3-17b-dione
2446-23-3
Mesterolon 1424-00-6
Methyltestosterone 58-18-4
5. picture

Details

1. how is the quality the qualities of most products are above 99% purity, same are 99.5% purity.
2, how is the package foil bag or as customers required.
3, how is the storage keep in dry and cool place.
4, do i need to pay extra for shipping cost no, our price includes the shipping cost already; you need not pay for any tax and others.
5, can i order sample to test yes, you are welcome to order sample before placing bulk order. we will send the sample directly to your door by courier.
6, minimum quantity usually our minimum quantity is 50g. but you are welcome to order samples to check the quality and our service.

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