Weight Loss Human Growth Hormone Peptide CAS137525-51-0 Adipotide For Anti

99% Purity Peptide Powder 2mg/Vial Adipotide For Weight Loss

Quick Detail:

Description:

Aditpotide is an experimental weight loss peptidomimetic with the amino acid sequence CKGGRAKDC-
GG-D(KLAKLAK)2, which has been developed by researchers in the United States in an effort to fight
obesity. Peptidomimetics are small protein-like chains designed to mimic a peptide. The peptide called
Adipotide has been developed by U.S. researchers in the fight against the obesity. This experimental
treatment has reduced by 11% the weight of the treated monkeys by reducing fatty tissue, the BMI, and
waist circumference.

Clinical Research studies have shown that the peptide-like compound, Adipotide, is able to kill fat cells
thereby causing a decrease in the volume and mass of the subcutaneous fat, and this in turn leads to
weight loss. Adipotide is able to kill the adipocytes (fat cells) by selectively causing programmed cell death
(apoptosis) of the blood vessels supplying the adipocytes. Due to the deprivation of nutrient supply, the
subsequent starvation (which causes cellular atrophy or decrease in cell size) and the accumulation of
waste products in the adipocytes; an irreversible injury occurs and this leads the mitochondria to release
protease enzymes called caspases (specific factors that initiate the apoptotic process) which activate the
transcription (a process whereby DNA is used to create mRNA) and translation (a process whereby mRNA
is used to create the nascent primary peptide) of gene sequences which ultimately leads to the production
of proteins that effect the apoptotic process.

Molecular studies have revealed that Adipotide possess a unique stereo-chemical (3D) conformation
which enables it to bind to only two receptors in the body: ANXA-2 and prohibitin. These receptors are
located on the surface of the endothelium (innermost wall lining) of the blood vessels supplying the white
adipocytes, and as such, these receptors confer tissue specificity to adipotide. Formation of white
adipocytes only occurs when the extent of energy consumption far exceeds energy utilization, and its
(white adipocytes) formation and accumulation in the subcutaneous layer serves as a hallmark of obesity.

Application:

Pathological studies have shown that obesity serves a risk factor for a myriad of diseases such as cancer,
hypertension, endocrine disorders(such as diabetes mellitus,hyperlipidemias and metabolic syndrome),
cardiovascular disease (such as stroke and myocardial infarctions) and degenerative diseases (such as
osteoarthritis). Moreover, aberrant accumulation of white adipocytes predisposes the affected individual to
lipoma and lipomatosis. It is well known that abdominal adiposity is mainly caused by white adipocytes, and
this form of adiposity is the most lipolytically active, thus requiring a steady blood supply. Any interference
with the blood supply causes it to activate the apoptotic process.

Adipotide is an experimental treatment that prevents the blood supply to fat cells. This has helped obese
monkeys to lose on average 11% of their body weight in four weeks, perhaps opening the way for therapy
in humans, according to a recent research study. The study, published in the journal Science.

Translational Medicine shows that body mass index and waist circumference of the rhesus monkeys were
reduced.

The experimental weight loss agent, "Adipotide" used by researchers at Anderson Center consists of a
substance that binds to a protein on the surface of blood vessels nourishing fat cells as well as a synthetic
peptide, destroying fat cells, say the authors of the study. These cells are then metabolized by the body
that destroys them and excreted. An imaging test also showed a significant reduction in fatty tissue in the
bodies of these animals compared to the untreated control group, the researchers suggest the Anderson
Center for Research on Cancer, University of Texas (South). " The obesity as well as smoking is a major
risk factor for cancer, "says Dr. Wadih Arap, professor of medicine at the Koch Center part of the
University of Texas, a major sponsor of this research.