CAS 1953-04-4 Legal Anabolic Steroids Nootropics Drug Galantamine Hydrobromide

Galantamine CAS 357-70-0 Pharmaceutical Raw Materials Nootropics Powders

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Description

Galanthamine,White or slightly yellow crystalline powder. Odorless, bitter taste. Melting point 127 ~ 129 ºC, [α] D20-118.8 ° (ethanol). Soluble in ethanol, acetone, chloroform, insoluble in benzene, ether and water. After reaction with ammonium molybdate solution, water bath, evaporate, sulfuric acid is added ,it turns to blue-green.

Use bulbs of Lycoris squamigera Maxim as raw material, under different acidity , extract and refine repeatedly with ethanol and chloroform to obtain the product . It belongs to anti-cholinesterase drugs.It is used for sequelae of infantile paralysis and myasthenia gravis. Medicinal use is its hydrobromide.

Alkaloids:

1. Galanthamine is alkaloid which is extracted from Amaryllidaceae plants Lycoris squamigera Maxim or Lycoris aurea,it is a reversible anti-cholinesterase drug, it is easy for it to go through the blood brain barrier into the brain tissue ,its effect on central nervous system is stronger.

2. it can improve neuromuscular conduction , compared with physostigmine, neostigmine , pyridostigmine , it has wide range of treatment, and low toxicity, muscarinic effects are weak and short-lived. Clinically Galanthamine is used not only for the treatment of myasthenia gravis, polio sequelae resting, but also for children with cerebral palsy, multiple neuritis, radiculitis and sensorimotor disorders caused by nervous system disease or trauma .

Application and Dosage

1. Galanthamine hydrobromide is used for myasthenia gravis, muscular dystrophy, polio sequelae, children cerebral palsy, sensory or motor disorders caused by neurological disorders , multiple neuritis.

2.The oral dosage form of the drug can be used for memory impairment, mild to moderate Alzheimers disease.
Oral: it is used for myasthenia gravis, muscular dystrophy, multiple peripheral neuropathy treatment: 1 10mg per time, tid. Children 0.5 ~ 1mg / (kg · d), 3 times.

3. It is used for Alzheimers disease: initial dose of 1 4mg, bid, for four weeks; maintenance dose of 8mg per time, bid, at least for four weeks; maximum maintenance dose of 1 times 12mg, bid.
Intramuscular or subcutaneous injection: 2.5 ~ 10mg / d, children each 0.05 ~ 0.1mg / kg, qd, 1 course is 2 to 6 weeks. Poliomyelitis continuous medication 40 ~ 50d, the general course of treatment is 20 ~ 40d, the start of the second compartment is 30 ~ 45d after treatment. After 1 to 2 courses ,if the condition has not been improved, patients should stop the medication. If it is effective ,3 courses can be used. Application of the dose should be small to large, in order to reduce adverse reactions.

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