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Sexual development

During male embryogenesis DHT has an essential role in the formation of the male external genitalia, while in the adult male DHT acts as the primary androgen in the prostate gland, seminal vesicles, skin, and hair follicles.

An example illustrating the significance of DHT for the development of secondary sex characteristics is congenital 5α-reductase type II deficiency. This genetic mutation can result in pseudohermaphroditism. The condition typically presents with underdeveloped male genitalia and prostate. Males with this condition are often raised as girls due to their lack of conspicuous male genitalia. At the onset of puberty, although their DHT levels remain very low,[citation needed] their testosterone levels elevate normally. Their musculature develops like that of other male adults. After puberty, men with this condition have a large deficiency of pubic and body hair and reportedly no incidence of androgenic alopecia (pattern hair loss). They also reportedly have no incidence of prostate cancer.

Unlike other androgens such as testosterone, DHT cannot be converted by the enzyme aromatase into an estrogen like estradiol. Therefore, it is frequently used in research settings to distinguish between the effects of testosterone caused by binding to the AR and those caused by testosterones conversion to estradiol and subsequent binding to and activation of estrogen receptors.

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